by T G Anthony, J C Anthony, M S Lewitt, S M Donovan and D K Layman
Abstract:
Prolonged exercise increases circulating insulin-like growth factor binding protein-1 (IGFBP-1) in humans and animals, but its physiological significance is unknown. This study examined 1) time-course changes in plasma IGFBP-1 and hepatic IGFBP-1 mRNA expression after exercise, 2) changes in IGFBP-1 in relation to plasma glucose, insulin, and IGF-I, and 3) the impact of feeding a postexercise meal on the IGFBP-1 response. Food-deprived male rats were vigorously run on a treadmill and compared with nonexercised controls at 15 min and 1, 4, 8, and 12 h after exercise. Circulating insulin concentrations in exercised rats were lower than in controls at 15 min and 1 h, whereas plasma glucose and IGF-I remained unaffected. Circulating and hepatic expression of IGFBP-1 was markedly increased above that of controls at 15 min, 1 h, and 12 h. In a separate experiment, one-half of the exercised animals received a nutritionally complete meal immediately after the experimental run. The meal elevated plasma insulin and glucose concentrations at 15 min and 1 h. Despite this change in nutritional status, serum IGFBP-1 concentrations and hepatic IGFBP-1 abundance remained elevated at 15 min and 1 h. These results demonstrate that the IGFBP-1 response to a single bout of treadmill exercise is short in duration and independent of insulin, glucose, and amino acid availability.
Reference:
Time course changes in IGFBP-1 after treadmill exercise and postexercise food intake in rats (T G Anthony, J C Anthony, M S Lewitt, S M Donovan and D K Layman), In Am J Physiol Endocrinol Metab, volume 280, 2001.
Bibtex Entry:
@article{Anthony:2001aa,
abstract = {Prolonged exercise increases circulating insulin-like growth factor binding protein-1 (IGFBP-1) in humans and animals, but its physiological significance is unknown. This study examined 1) time-course changes in plasma IGFBP-1 and hepatic IGFBP-1 mRNA expression after exercise, 2) changes in IGFBP-1 in relation to plasma glucose, insulin, and IGF-I, and 3) the impact of feeding a postexercise meal on the IGFBP-1 response. Food-deprived male rats were vigorously run on a treadmill and compared with nonexercised controls at 15 min and 1, 4, 8, and 12 h after exercise. Circulating insulin concentrations in exercised rats were lower than in controls at 15 min and 1 h, whereas plasma glucose and IGF-I remained unaffected. Circulating and hepatic expression of IGFBP-1 was markedly increased above that of controls at 15 min, 1 h, and 12 h. In a separate experiment, one-half of the exercised animals received a nutritionally complete meal immediately after the experimental run. The meal elevated plasma insulin and glucose concentrations at 15 min and 1 h. Despite this change in nutritional status, serum IGFBP-1 concentrations and hepatic IGFBP-1 abundance remained elevated at 15 min and 1 h. These results demonstrate that the IGFBP-1 response to a single bout of treadmill exercise is short in duration and independent of insulin, glucose, and amino acid availability.},
author = {Anthony, T G and Anthony, J C and Lewitt, M S and Donovan, S M and Layman, D K},
date-added = {2023-07-23 20:37:13 +0100},
date-modified = {2023-07-23 20:37:13 +0100},
doi = {10.1152/ajpendo.2001.280.4.E650},
journal = {Am J Physiol Endocrinol Metab},
journal-full = {American journal of physiology. Endocrinology and metabolism},
keywords = {Protein Synthesis},
mesh = {Animals; Blood Glucose; Eating; Insulin; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Liver; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Time Factors},
month = {Apr},
number = {4},
pages = {E650-6},
pmid = {11254473},
pst = {ppublish},
title = {Time course changes in IGFBP-1 after treadmill exercise and postexercise food intake in rats},
volume = {280},
year = {2001},
bdsk-url-1 = {https://doi.org/10.1152/ajpendo.2001.280.4.E650}}