@article{Devkota:2010aa,
	abstract = {PURPOSE OF REVIEW: To understand the potential benefits of increased dietary protein during weight loss and the importance of distribution of high-quality protein at each meal.
RECENT FINDINGS: Popular weight loss diets emphasize use of protein as a substitute for carbohydrates or fat to reduce insulin and minimize hunger and food cravings. These diets produce short-term weight loss, but long-term benefits remain obscured by failure to differentiate between outcomes of subject compliance and diet effectiveness. New molecular mechanisms have defined the benefits of protein as a meal threshold for the branched-chain amino acid leucine, which has been characterized as a unique signal regulator of muscle protein synthesis. Leucine consumed at 2.5 g triggers a postmeal anabolic response that protects metabolic active tissues during weight loss and increases loss of body fat.
SUMMARY: Balanced daily distribution of protein with increased intake at breakfast and lunch protects metabolically active tissues including skeletal muscle during weight loss.},
	author = {Devkota, Suzanne and Layman, Donald K},
	date-added = {2023-07-23 20:37:13 +0100},
	date-modified = {2023-07-23 20:37:13 +0100},
	doi = {10.1097/MCO.0b013e32833a7737},
	journal = {Curr Opin Clin Nutr Metab Care},
	journal-full = {Current opinion in clinical nutrition and metabolic care},
	keywords = {Protein Synthesis},
	mesh = {Adipose Tissue; Diet, Reducing; Dietary Proteins; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Obesity; Patient Compliance; Treatment Outcome; Weight Loss},
	month = {Jul},
	number = {4},
	pages = {403-7},
	pmid = {20531180},
	pst = {ppublish},
	title = {Protein metabolic roles in treatment of obesity},
	volume = {13},
	year = {2010},
	bdsk-url-1 = {https://doi.org/10.1097/MCO.0b013e32833a7737}}