by S R Glore and D K Layman
Abstract:
The cellular basis for growth retardation of skeletal muscle was studied in male Sprague-Dawley rats. At birth, animals were assigned to control (C) or food-restricted (R) groups. During lactation, food intake of the pups was reduced by limiting intake of the mother to 50% of controls. After weaning, pups received 40% of ad libitum intakes until 120 d of age. From 120 to 316 d, all animals were fed ad libitum. At 120 d, body weight of the R group was 41% of C and muscle and adipose weights were 54 and 16% of C, respectively. Muscle DNA in the R group was 47% of C, but protein-to-DNA ratio was normal. Fiber number was not different between C and R groups; however, muscle length and fiber cross-sectional area were 85 and 64%, respectively, of C values. After 196 d of recovery, weights of the body, skeletal muscles and adipose tissues averaged 76, 84 and 51% of C values, respectively. Recovery of skeletal muscle paralleled the recovery of fiber cross-sectional area (84%) and DNA content (86%). Daily injections of 100 micrograms of growth hormone from 120 to 148 d produced no additional recovery. This study establishes that growth retardation of skeletal muscle is associated with reductions in the development of cross-sectional area and DNA content of muscle fibers.
Reference:
Cellular development of skeletal muscle of rats during recovery from prolonged undernutrition (S R Glore and D K Layman), In J Nutr, volume 117, 1987.
Bibtex Entry:
@article{Glore:1987aa,
abstract = {The cellular basis for growth retardation of skeletal muscle was studied in male Sprague-Dawley rats. At birth, animals were assigned to control (C) or food-restricted (R) groups. During lactation, food intake of the pups was reduced by limiting intake of the mother to 50% of controls. After weaning, pups received 40% of ad libitum intakes until 120 d of age. From 120 to 316 d, all animals were fed ad libitum. At 120 d, body weight of the R group was 41% of C and muscle and adipose weights were 54 and 16% of C, respectively. Muscle DNA in the R group was 47% of C, but protein-to-DNA ratio was normal. Fiber number was not different between C and R groups; however, muscle length and fiber cross-sectional area were 85 and 64%, respectively, of C values. After 196 d of recovery, weights of the body, skeletal muscles and adipose tissues averaged 76, 84 and 51% of C values, respectively. Recovery of skeletal muscle paralleled the recovery of fiber cross-sectional area (84%) and DNA content (86%). Daily injections of 100 micrograms of growth hormone from 120 to 148 d produced no additional recovery. This study establishes that growth retardation of skeletal muscle is associated with reductions in the development of cross-sectional area and DNA content of muscle fibers.},
author = {Glore, S R and Layman, D K},
date-added = {2023-07-23 20:37:13 +0100},
date-modified = {2023-07-23 20:37:13 +0100},
doi = {10.1093/jn/117.10.1767},
journal = {J Nutr},
journal-full = {The Journal of nutrition},
keywords = {Protein Synthesis},
mesh = {Animals; Biometry; Body Weight; DNA; Female; Food; Growth Hormone; Male; Muscle Development; Muscle Proteins; Muscles; Nutrition Disorders; Organ Size; Rats; Rats, Inbred Strains},
month = {Oct},
number = {10},
pages = {1767-74},
pmid = {3668692},
pst = {ppublish},
title = {Cellular development of skeletal muscle of rats during recovery from prolonged undernutrition},
volume = {117},
year = {1987},
bdsk-url-1 = {https://doi.org/10.1093/jn/117.10.1767}}