by Tanya M Holloway, Robert W Morton, Sara Y Oikawa, Sean McKellar, Steven K Baker and Stuart M Phillips
Abstract:
Resistance training promotes microvasculature expansion; however, it remains unknown how different resistance training programs contribute to angiogenesis. Thus, we recruited experienced resistance-trained participants and determined the effect of 12 wk of either high-repetition/low-load or low-repetition/high-load resistance training performed to volitional fatigue on muscle microvasculature. Twenty men performed either a high-repetition [20-25 repetitions, 30-50% of 1-repetition maximum (1RM); n = 10] or a low-repetition (8-12 repetitions, 75-90% of 1RM; n = 10) resistance training program. Muscle biopsies were taken before and after resistance training, and immunohistochemistry was used to assess fiber type (I and II)-specific microvascular variables. High-repetition/low-load and low-repetition/high-load groups were not different in any variable before resistance training. Both protocols resulted in an increase in capillarization. Specifically, after resistance training, the capillary-to-fiber ratio, capillary contacts, and capillary-to-fiber perimeter exchange index were elevated, and sharing factor was reduced. These data demonstrate that resistance training performed to volitional failure, using either high repetition/low load or low repetition/high load, induced similar microvascular adaptations in recreationally resistance-trained young men.
Reference:
Microvascular adaptations to resistance training are independent of load in resistance-trained young men (Tanya M Holloway, Robert W Morton, Sara Y Oikawa, Sean McKellar, Steven K Baker and Stuart M Phillips), In Am J Physiol Regul Integr Comp Physiol, volume 315, 2018.
Bibtex Entry:
@article{Holloway:2018aa,
abstract = {Resistance training promotes microvasculature expansion; however, it remains unknown how different resistance training programs contribute to angiogenesis. Thus, we recruited experienced resistance-trained participants and determined the effect of 12 wk of either high-repetition/low-load or low-repetition/high-load resistance training performed to volitional fatigue on muscle microvasculature. Twenty men performed either a high-repetition [20-25 repetitions, 30-50% of 1-repetition maximum (1RM); n = 10] or a low-repetition (8-12 repetitions, 75-90% of 1RM; n = 10) resistance training program. Muscle biopsies were taken before and after resistance training, and immunohistochemistry was used to assess fiber type (I and II)-specific microvascular variables. High-repetition/low-load and low-repetition/high-load groups were not different in any variable before resistance training. Both protocols resulted in an increase in capillarization. Specifically, after resistance training, the capillary-to-fiber ratio, capillary contacts, and capillary-to-fiber perimeter exchange index were elevated, and sharing factor was reduced. These data demonstrate that resistance training performed to volitional failure, using either high repetition/low load or low repetition/high load, induced similar microvascular adaptations in recreationally resistance-trained young men.},
author = {Holloway, Tanya M and Morton, Robert W and Oikawa, Sara Y and McKellar, Sean and Baker, Steven K and Phillips, Stuart M},
date-added = {2023-01-08 10:35:40 +0000},
date-modified = {2023-01-08 12:17:03 +0000},
doi = {10.1152/ajpregu.00118.2018},
journal = {Am J Physiol Regul Integr Comp Physiol},
journal-full = {American journal of physiology. Regulatory, integrative and comparative physiology},
keywords = {Muscle},
mesh = {Adaptation, Physiological; Age Factors; Body Composition; Humans; Male; Microvessels; Mitochondria, Muscle; Muscle Contraction; Muscle Strength; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Ontario; Oxidative Phosphorylation; Resistance Training; Sex Factors; Time Factors; Vascular Endothelial Growth Factor A; Young Adult},
month = {Aug},
number = {2},
pages = {R267-R273},
pmc = {PMC6139617},
pmid = {29897821},
pst = {ppublish},
title = {Microvascular adaptations to resistance training are independent of load in resistance-trained young men},
url = {http://nelsontavares.com/r/papers/Microvascular%20adaptations%20to%20resistance%20training%20are%20independent%20of%20load%20inresistance-trained%20young%20men.pdf},
volume = {315},
year = {2018},
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