@article{Johansen:2023aa,
	abstract = {Distinct gut microbiome ecology may be implicated in the prevention of aging-related diseases as it influences systemic immune function and resistance to infections. Yet, the viral component of the microbiome throughout different stages in life remains unexplored. Here we present a characterization of the centenarian gut virome using previously published metagenomes from 195 individuals from Japan and Sardinia. Compared with gut viromes of younger adults (>18 yr) and older individuals (>60 yr), centenarians had a more diverse virome including previously undescribed viral genera, such as viruses associated with Clostridia. A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that influence bacterial physiology, which revealed an enrichment of genes supporting key steps in sulfate metabolic pathways. Phage and bacterial members of the centenarian microbiome displayed an increased potential for converting methionine to homocysteine, sulfate to sulfide and taurine to sulfide. A greater metabolic output of microbial hydrogen sulfide in centenarians may in turn support mucosal integrity and resistance to pathobionts.},
	address = {Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.; Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.; Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.; Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland.; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. rxavier@broadinstitute.org.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. simon.rasmussen@cpr.ku.dk.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. simon.rasmussen@cpr.ku.dk.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. damian@broadinstitute.org.},
	auid = {ORCID: 0000-0001-7052-1870; ORCID: 0000-0001-5422-0736; ORCID: 0000-0001-6227-9906; ORCID: 0000-0003-0949-1291; ORCID: 0000-0003-0474-0033; ORCID: 0000-0001-8937-9835; ORCID: 0000-0002-5630-5167; ORCID: 0000-0001-6323-9041; ORCID: 0000-0002-6555-2557},
	author = {Johansen, Joachim and Atarashi, Koji and Arai, Yasumichi and Hirose, Nobuyoshi and S{\o}rensen, S{\o}ren J and Vatanen, Tommi and Knip, Mikael and Honda, Kenya and Xavier, Ramnik J and Rasmussen, Simon and Plichta, Damian R},
	copyright = {{\copyright}2023. The Author(s), under exclusive licence to Springer Nature Limited.},
	crdt = {2023/05/15 23:24},
	date = {2023 Jun},
	date-added = {2023-06-05 08:22:28 +0100},
	date-modified = {2023-06-05 08:22:28 +0100},
	dep = {20230515},
	doi = {10.1038/s41564-023-01370-6},
	edat = {2023/05/16 01:09},
	gr = {NNF14CC0001/Novo Nordisk/},
	issn = {2058-5276 (Electronic); 2058-5276 (Linking)},
	jid = {101674869},
	journal = {Nat Microbiol},
	jt = {Nature microbiology},
	keywords = {Aged},
	language = {eng},
	lid = {10.1038/s41564-023-01370-6 {$[$}doi{$]$}},
	lr = {20230604},
	mhda = {2023/05/16 01:09},
	month = {Jun},
	number = {6},
	own = {NLM},
	pages = {1064--1078},
	phst = {2022/09/12 00:00 {$[$}received{$]$}; 2023/03/23 00:00 {$[$}accepted{$]$}; 2023/05/16 01:09 {$[$}pubmed{$]$}; 2023/05/16 01:09 {$[$}medline{$]$}; 2023/05/15 23:24 {$[$}entrez{$]$}},
	pii = {10.1038/s41564-023-01370-6},
	pl = {England},
	pmid = {37188814},
	pst = {ppublish},
	pt = {Journal Article},
	sb = {IM},
	status = {In-Process},
	title = {Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan.},
	volume = {8},
	year = {2023},
	bdsk-url-1 = {https://doi.org/10.1038/s41564-023-01370-6}}