by D K Layman, P B Swan and P V Hegarty
Abstract:
1. Male Sprague-Dawley rats were allocated at 100 g into either an ad lib.-fed control group or a food-restricted group. The restricted group was fed for 9 d at 25% of ad lib. intake. Controls were killed at a body-weight of 100 g and 29 d of age. 2. The effects of food restriction on muscle weight, fibre number, fibre diameter, DNA, and protein were examined in three skeletal muscles, the soleus, plantaris and extensor digitorum longus (EDL). 3. Acute dietary restriction caused body- and muscle-weight loss and a decrease in both the number and cross-sectional area of muscle fibres in each of the muscles. 4. The restriction halted growth-related increases in DNA in all muscles and decreased the protein:DNA value in the plantaris and EDL. 5. These results indicate that present theories describing cellular development are not adequate to define growth potential or growth retardation of skeletal muscle.
Reference:
The effect of acute dietary restriction on muscle fibre number in weanling rats (D K Layman, P B Swan and P V Hegarty), In Br J Nutr, volume 45, 1981.
Bibtex Entry:
@article{Layman:1981ab,
abstract = {1. Male Sprague-Dawley rats were allocated at 100 g into either an ad lib.-fed control group or a food-restricted group. The restricted group was fed for 9 d at 25% of ad lib. intake. Controls were killed at a body-weight of 100 g and 29 d of age. 2. The effects of food restriction on muscle weight, fibre number, fibre diameter, DNA, and protein were examined in three skeletal muscles, the soleus, plantaris and extensor digitorum longus (EDL). 3. Acute dietary restriction caused body- and muscle-weight loss and a decrease in both the number and cross-sectional area of muscle fibres in each of the muscles. 4. The restriction halted growth-related increases in DNA in all muscles and decreased the protein:DNA value in the plantaris and EDL. 5. These results indicate that present theories describing cellular development are not adequate to define growth potential or growth retardation of skeletal muscle.},
author = {Layman, D K and Swan, P B and Hegarty, P V},
date-added = {2023-07-23 20:37:13 +0100},
date-modified = {2023-07-23 20:37:13 +0100},
doi = {10.1079/bjn19810126},
journal = {Br J Nutr},
journal-full = {The British journal of nutrition},
keywords = {Protein Synthesis},
mesh = {Animals; Body Weight; Food Deprivation; Heart; Liver; Male; Muscles; Organ Size; Rats},
month = {May},
number = {3},
pages = {475-81},
pmid = {7236577},
pst = {ppublish},
title = {The effect of acute dietary restriction on muscle fibre number in weanling rats},
volume = {45},
year = {1981},
bdsk-url-1 = {https://doi.org/10.1079/bjn19810126}}