@article{Mojtahedi:2011aa,
	abstract = {BACKGROUND: The purpose of this double-blind randomized clinical trial was to compare the relative effectiveness of a higher protein and conventional carbohydrate intake during weight loss on body composition and physical function in older women.
METHODS: Thirty-one overweight or obese, postmenopausal women (mean $\pm$ SD: age 65.2 $\pm$ 4.6 years, body mass index 33.7 $\pm$ 4.9 kg/m(2)) were prescribed a reduced calorie diet (1,400 kcal/day; 15%, 65%, 30% energy from protein, carbohydrate, and fat, respectively) and randomly assigned to 2 × 25 g/day whey protein (PRO n = 15) or maltodextrin (CARB n = 16) supplementation for 6 months. Lean soft tissue (LST) via dual-energy X-ray absorptiometry; thigh muscle, subcutaneous adipose tissue (SAT), and intermuscular adipose tissue with magnetic resonance imaging; knee strength with isokinetic dynamometry; balance and physical function with a battery of performance tests.
RESULTS: PRO lost more weight than CARB (-8.0% $\pm$ 6.2%, -4.1% $\pm$ 3.6%, p = .059; respectively). Changes in LST, %LST, and strength, balance, or physical performance measures did not differ between groups (all p > .05). Weight to leg LST ratio improved more in PRO versus CARB (-4.6 $\pm$ 3.6%, -1.8 $\pm$ 2.6%, p = .03). PRO lost 4.2% more muscle (p = .01), 10.9% more SAT (p = .02), and 8.2% more intermuscular adipose tissue (p = .03) than CARB. Relative to thigh volume changes, PRO gained 5.8% more muscle (p = .049) and lost 3.8% greater SAT (p = .06) than CARB. Weight to leg LST ratio (r(2) = .189, p = .02) and SAT (r(2) = .163, p = .04) predicted improved up and go, relative muscle (r(2) = .238, p = .01) and SAT (r(2) = .165, p = .04) predicted improved transfer test, and %LST predicted improved balance (r(2) = .179, p = .04).
CONCLUSIONS: A higher protein intake during caloric restriction maintains muscle relative to weight lost, which in turn enhances physical function in older women.},
	author = {Mojtahedi, Mina C and Thorpe, Matthew P and Karampinos, Dimitrios C and Johnson, Curtis L and Layman, Donald K and Georgiadis, John G and Evans, Ellen M},
	date-added = {2023-07-23 20:37:13 +0100},
	date-modified = {2023-07-23 20:37:13 +0100},
	doi = {10.1093/gerona/glr120},
	journal = {J Gerontol A Biol Sci Med Sci},
	journal-full = {The journals of gerontology. Series A, Biological sciences and medical sciences},
	keywords = {Protein Synthesis},
	mesh = {Aged; Body Composition; Caloric Restriction; Dietary Carbohydrates; Dietary Proteins; Double-Blind Method; Exercise; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Muscle Strength; Muscle, Skeletal; Weight Loss},
	month = {Nov},
	number = {11},
	pages = {1218-25},
	pmid = {21798863},
	pst = {ppublish},
	title = {The effects of a higher protein intake during energy restriction on changes in body composition and physical function in older women},
	volume = {66},
	year = {2011},
	bdsk-url-1 = {https://doi.org/10.1093/gerona/glr120}}