by Christopher J Moulton, Rudy J Valentine, Donald K Layman, Suzanne Devkota, Keith W Singletary, Matthew A Wallig and Sharon M Donovan
Abstract:
Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of breast tissue carcinomas. Mammary tumors were induced by N-methyl-N-nitrosourea (MNU) at 52 d of age. Post-induction, animals were assigned to consume either a low protein high carbohydrate diet (LPHC; 15% and 60% of energy, respectively) or a high protein moderate carbohydrate diet (HPMC; 35% and 40% of energy, respectively) for 10 wk. Animals were fed 3 meals/day to mimic human absorption and metabolism patterns. The rate of palpable tumor incidence was reduced in HPMC relative to LPHC (12.9 +/- 1.4%/wk vs. 18.2 +/- 1.3%/wk). At 3 wk, post-prandial serum insulin was larger in the LPHC relative to HPMC (+136.4 +/- 33.1 pmol/L vs. +38.1 +/- 23.4 pmol/L), while at 10 wk there was a trend for post-prandial IGF-I to be increased in HPMC (P = 0.055). There were no differences in tumor latency, tumor surface area, or cumulative tumor mass between diet groups. The present study provides evidence that reducing the dietary carbohydrate:protein ratio attenuates the development of mammary tumors. These findings are consistent with reduced post-prandial insulin release potentially diminishing the proliferative environment required for breast cancer tumors to progress.
Reference:
A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats (Christopher J Moulton, Rudy J Valentine, Donald K Layman, Suzanne Devkota, Keith W Singletary, Matthew A Wallig and Sharon M Donovan), In Nutr Metab (Lond), volume 7, 2010.
Bibtex Entry:
@article{Moulton:2010aa,
abstract = {Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of breast tissue carcinomas. Mammary tumors were induced by N-methyl-N-nitrosourea (MNU) at 52 d of age. Post-induction, animals were assigned to consume either a low protein high carbohydrate diet (LPHC; 15% and 60% of energy, respectively) or a high protein moderate carbohydrate diet (HPMC; 35% and 40% of energy, respectively) for 10 wk. Animals were fed 3 meals/day to mimic human absorption and metabolism patterns. The rate of palpable tumor incidence was reduced in HPMC relative to LPHC (12.9 +/- 1.4%/wk vs. 18.2 +/- 1.3%/wk). At 3 wk, post-prandial serum insulin was larger in the LPHC relative to HPMC (+136.4 +/- 33.1 pmol/L vs. +38.1 +/- 23.4 pmol/L), while at 10 wk there was a trend for post-prandial IGF-I to be increased in HPMC (P = 0.055). There were no differences in tumor latency, tumor surface area, or cumulative tumor mass between diet groups. The present study provides evidence that reducing the dietary carbohydrate:protein ratio attenuates the development of mammary tumors. These findings are consistent with reduced post-prandial insulin release potentially diminishing the proliferative environment required for breast cancer tumors to progress.},
author = {Moulton, Christopher J and Valentine, Rudy J and Layman, Donald K and Devkota, Suzanne and Singletary, Keith W and Wallig, Matthew A and Donovan, Sharon M},
date-added = {2023-07-23 20:37:13 +0100},
date-modified = {2023-07-23 20:37:13 +0100},
doi = {10.1186/1743-7075-7-1},
journal = {Nutr Metab (Lond)},
journal-full = {Nutrition \& metabolism},
keywords = {Protein Synthesis},
month = {Jan},
pages = {1},
pmc = {PMC2819246},
pmid = {20148110},
pst = {epublish},
title = {A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats},
volume = {7},
year = {2010},
bdsk-url-1 = {https://doi.org/10.1186/1743-7075-7-1}}