by Daniel Cuevas-Ramos, Paloma Almeda-Valdés, Clara Elena Meza-Arana, Griselda Brito-Córdova, Francisco J. Gómez-Pérez, Roopa Mehta, Jorge Oseguera-Moguel and Carlos A. Aguilar-Salinas
Abstract:
BACKGROUND: Fibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise. METHODOLOGY/PRINCIPAL FINDINGS: This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily supervised exercise. The study sample was composed of 60 sedentary young healthy women. The mean age was 24$\pm$3.7 years old, and the mean BMI was 21.4$\pm$7.0 kg/m². The anthropometric characteristics did not change after two weeks of exercise. FGF21 levels significantly increased after two weeks of exercise (276.8 ng/l (142.8-568.6) vs. (460.8 (298.2-742.1), p\textless0.0001)). The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r = 0.23, p = 0.04), mean maximal heart rate (MHR) (r = 0.54, p\textless0.0001), mean METs (r = 0.40, p = 0.002), delta plasma epinephrine (r = 0.53, p\textless0.0001) and delta plasma FFAs (r = 0.35, p = 0.006). A stepwise linear regression model showed that glucose, MHR, METs, FFAs, and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F = 4.32; r² = 0.64, p\textless0.0001). CONCLUSIONS: Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise. TRIAL REGISTRATION: ClinicalTrials.gov NCT01512368.
Reference:
Exercise increases serum fibroblast growth factor 21 (FGF21) levels (Daniel Cuevas-Ramos, Paloma Almeda-Valdés, Clara Elena Meza-Arana, Griselda Brito-Córdova, Francisco J. Gómez-Pérez, Roopa Mehta, Jorge Oseguera-Moguel and Carlos A. Aguilar-Salinas), In PloS One, volume 7, 2012.
Bibtex Entry:
@article{cuevas-ramos_exercise_2012,
abstract = {BACKGROUND: Fibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise.
METHODOLOGY/PRINCIPAL FINDINGS: This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily supervised exercise. The study sample was composed of 60 sedentary young healthy women. The mean age was 24$\pm$3.7 years old, and the mean BMI was 21.4$\pm$7.0 kg/m². The anthropometric characteristics did not change after two weeks of exercise. FGF21 levels significantly increased after two weeks of exercise (276.8 ng/l (142.8-568.6) vs. (460.8 (298.2-742.1), p{\textless}0.0001)). The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r = 0.23, p = 0.04), mean maximal heart rate (MHR) (r = 0.54, p{\textless}0.0001), mean METs (r = 0.40, p = 0.002), delta plasma epinephrine (r = 0.53, p{\textless}0.0001) and delta plasma FFAs (r = 0.35, p = 0.006). A stepwise linear regression model showed that glucose, MHR, METs, FFAs, and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F = 4.32; r² = 0.64, p{\textless}0.0001).
CONCLUSIONS: Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01512368.},
author = {Cuevas-Ramos, Daniel and Almeda-Vald{\'e}s, Paloma and Meza-Arana, Clara Elena and Brito-C{\'o}rdova, Griselda and G{\'o}mez-P{\'e}rez, Francisco J. and Mehta, Roopa and Oseguera-Moguel, Jorge and Aguilar-Salinas, Carlos A.},
date-modified = {2023-01-08 11:48:25 +0000},
doi = {10.1371/journal.pone.0038022},
issn = {1932-6203},
journal = {PloS One},
keywords = {Exercise},
language = {eng},
number = {5},
pages = {e38022},
pmcid = {PMC3365112},
pmid = {22701542},
title = {Exercise increases serum fibroblast growth factor 21 ({FGF21}) levels},
volume = {7},
year = {2012},
bdsk-url-1 = {https://doi.org/10.1371/journal.pone.0038022}}