by Marc L. Reitman
Abstract:
A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism (Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARalpha transcription factor, is a "missing link" in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.
Reference:
FGF21: a missing link in the biology of fasting (Marc L. Reitman), In Cell Metabolism, volume 5, 2007.
Bibtex Entry:
@article{reitman_fgf21_2007,
abstract = {A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism (Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARalpha transcription factor, is a "missing link" in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.},
author = {Reitman, Marc L.},
date-modified = {2023-01-07 15:11:26 +0000},
doi = {10.1016/j.cmet.2007.05.010},
issn = {1932-7420},
journal = {Cell Metabolism},
keywords = {Fasting},
language = {eng},
month = jun,
number = {6},
pages = {405--407},
pmid = {17550773},
shorttitle = {{FGF21}},
title = {{FGF21}: a missing link in the biology of fasting},
volume = {5},
year = {2007},
bdsk-url-1 = {https://doi.org/10.1016/j.cmet.2007.05.010}}