@article{womack_effects_2015,
	abstract = {BACKGROUND: The purpose of this project was to examine the effects of acute garlic supplementation on fibrinolysis and vasoreactivity both at rest and following maximal exercise.
METHODS: Eighteen healthy trained males (20.9 $\pm$ 2.2 years, 178 $\pm$ 7.7 cm, 75.5 $\pm$ 9.6 kg, VO2max = 59.8 $\pm$ 6.7 ml * kg(-1) * min(-1)) performed a graded treadmill test to volitional exhaustion. Blood samples were taken at rest, within two minutes post-exercise, and one hour post-exercise. Eleven of the subjects also had a brachial vasoreactivity test performed immediately after the blood sample to assess flow-mediated dilation (FMD) of the brachial artery. Participants were randomly assigned to ingest either 900 mg of powdered garlic or a placebo three hours before the exercise session. The supplement was distributed in a double-blind, crossover fashion. Participants repeated the protocol with the other treatment after a 14-day washout period. Paired t-tests were used to compare VO2max between the two trials. A two-factor (treatment and time) repeated measures analysis of variance (ANOVA) was used to assess changes in FMD, tPA activity, tPA antigen, and PAI-1 activity. A priori statistical significance was set at P {\textless}0.05.
RESULTS: VO2max was greater for the garlic treatment trial vs. placebo (Placebo = 59.8 $\pm$ 6.7 ml * kg(-1) * min(-1); Garlic = 61.4 $\pm$ 6.6 ml * kg(-1) * min(-1)). There was no main effect for treatment and no treatment x time interaction for FMD or any fibrinolytic variables examined.
CONCLUSION: Acute garlic supplementation does not alter vasoreactivity, fibrinolytic potential or the fibrinolytic response to exercise in young healthy trained males. Acute garlic supplementation does, however, cause a small but statistically significant increase in VO2max. It remains unclear if this increase in VO2max is of functional importance.},
	author = {Womack, C. J. and Lawton, D. J. and Redmond, L. and Todd, M. K. and Hargens, T. A.},
	date-modified = {2023-01-07 18:54:01 +0000},
	doi = {10.1186/s12970-015-0084-9},
	issn = {1550-2783},
	journal = {Journal of the International Society of Sports Nutrition},
	keywords = {Garlic, Exercise},
	language = {eng},
	pages = {23},
	pmcid = {PMC4446086},
	pmid = {26019694},
	title = {The effects of acute garlic supplementation on the fibrinolytic and vasoreactive response to exercise},
	volume = {12},
	year = {2015},
	bdsk-url-1 = {https://doi.org/10.1186/s12970-015-0084-9}}